UJR 2013, vol XXI, # 2
THE CONTENTS
2013, vol XXI, # 2, page 131
I.M. Pylypenko, M.I. Pylypenko
New evidence-based approaches to management of patients with prostate cancer
Key words: prostate cancer, patient management, evidence based medicine.
2013, vol XXI, # 2, page 139
V.A. Vinnikov, N.A. Maznyk, T.S. Sypko, N.D. Pshenichna
The cytogenetic damage in gynaecological cancer patients during radiotherapy. I. The variability of cytogenetic response to irradiation
Objectives: To evaluate the limits of cytogenetic changes in blood lymphocytes of gynecological cancer patients undergoing radiotherapy and to assess the individual variability of the kinetics of chromosome aberration yields depending on treatment schemes.
Materials and methods: Cytogenetic study was carried out in 53 female patients with uterine cancer (UCa), 5 cervical cancer patients (CCa) and 12 ovarian cancer patients (OCa), who underwent standard cources of telegammatherapy (TGT, 38 persons), intracavitary brachytherapy (ICBT, 10 persons) or a combination of both (CRT, 22 persons). Conventional cytogenetic analysis aimed at recording chromosomal aberrations and genomic abnormalities, was performed in 50-h lymphocyte cultures, set up from samples collected before irradiation and throughout the radiotherapy (RT) course; in total 186 individual examinations was done. For each patient the individual rate of accumulation of unstable chromosome type aberration yield (ACsunst) was calculated in terms of a regression "the number of RT fractions - effect"; the variation coefficient for this parameter was estimated inside the groups. The changes in the average kinetics of cytogenetic effects throughout the RT course were analyzed.
Results: Any studied RT scheme produced a significant elevation of cytogenetic damage yield in patients' lymphocytes that occurred nearly exclusively due to accumulation of ACsunst. The ranges of individual aberration yields were essentially overlapped in TGT and CRT groups, and in both groups markedly exceeded the respective parameters in ICBT group. The individual rates of the ACsunst accumulation varied from 2 to 23 times between persons of the same RT group studied at similar treatment stage. Among 32 patients, who were followed up individually in the middle and the end of the RT course, there were 13 cases of the linear increase of the ACsunst yield, 4 cases of acceleration of the kinetics from the middle to the end of the RT course and 15 cases of plateauing or decrease of aberration yield in the second part of RT. The variation coefficient for the accumulation rate of the ACsunst ranged from 50 to 80 % at different stages of RT; the average value for the studied cohort was about 70 %. This parameter increased throughout the RT course in all groups independently on the RT scheme.
Conclusions: For the first time in vivo aberration yields were compared in the representational groups of gynecological cancer patients undergoing telegammatherapy, intracavital brachytherapy or their combination; the limits of cytogenetic changes were evaluated and the magnitude of the individual variability of kinetics of cytogenetic damage yield was assessed depending on the scheme of therapeutic irradiation. These data are basic for the appraisal of the prognostic value of cytogenetic damage as clinically-meaningful markers during RT.
Key words: chromosome aberrations, radiotherapy, uterine cancer, ovarian cancer.
2013, vol XXI, # 2, page 151
6th INTERNATIONAL CONGRESS OF UKRAINIAN SOCIETY OF RADIATION ONCOLOGISTS
JUNE 25-27 2013, RIVNE PROCEEDINGS OF THE CONGRESS
2013, vol XXI, # 2, page 152
O.Yu. Anykeeva, P.V. Fylatov, O.A. Pashkovskaya
Dose selection in lung cancer patients with cardiovascular diseases
Summary. The authors feature the technology of high-dose stereotactic radiation therapy in patients with non-small-cell lung cancer with pathology of the cardiovascular system when a system of active control of the patient's breathing is used. Forty-two patients were treated on a linear accelerator Elekta Axesse in 3-4 fractions, 12-18 Gy per fraction. It is shown that the method allows to reach high tumor control without increasing the load on the cardiovascular system.
Key words: non-small-cell lung cancer, radiation therapy, disorders of the cardiovascular system.
2013, vol XXI, # 2, page 154
S.V. Antypova, V.T. Radomskyy, N.M. Serohina, V. I. Kotylevska, V.V. Serohin, D.O. Stryukov
Comparative analysis of the methods of treatment by the results of three-year relapse-free survival of the patients with stage II bladder
cancer
Summary. The authors compare the efficacy of treatment methods using the data about three-year relapse-free survival of the patients with stage II bladder cancer. It is desirable to use combination treatment (stage 1 - transurethral resection and stage 2 radiation therapy), which allows to reduce the frequency of relapses and progression of the disease and, respectively, increase relapse-free survival of the patients.
Key words: bladder cancer, transurethral resection, radiation therapy.
2013, vol XXI, # 2, page 156
N.V. Bilozor, V.P. Starenkyy, O.M. Sukhina
Influence of clinical characteristics on radiation therapy effect in patients with stage III non-small-cell lung cancer at non-standard fractionation modes
Summary. A comparative analysis of different modes of radiotherapy fractionation with modification using etoposide and cisplatin in patients with non-small-cell lung cancer is given. Objective response was significantly higher in the accelerated fractionation modes, while the frequency of positive response depended on the general condition of the patient, the extent of the tumor process, morphology, growth form. Accelerated hyperfractionated modes in combination with chemotherapy modification provides a statistically significant improvement general and relapse-free survival. The general condition of the patient, the form of the macroscopic tumor growth, the degree of tumor regression are prognostically significant for stage III non-small-cell lung cancer.
Key words: non-small cell lung cancer, radiation therapy, accelerated fractionation modes, objective response, overall survival, relapse-free survival.
2013, vol XXI, # 2, page 161
T. H. Boyko, I.V. Smahlyuk, T.V. Onitseva, I.M. Makaruk, K. V. Yarynich
Analysis of cases of skin cancer relapses on the site of removed (cured) tumors
Summary. The authors analyze development of relapses of skin cancer relapses in the sites of removed (cured) tumors. It was established that the highest frequency of relapses occurred after radiation therapy for the tumors of the head and neck on the 2nd and 3rd year of observation. In the majority of cases postoperative skin cancer relapses occurred on the 1st year of observation (from month 1 to month 8).
Key words: non-melanoma skin cancer, radiation therapy, relapse.
2013, vol XXI, # 2, page 163
H. V. Bondar, I.YE. Syedakov, N.H. Semykoz, V.M. Smyrnov, D.V. Trukhin, YE.Yu. Khlopushyn, V.P. Fefelova, O. O. Hrabovskyy
The variants of treatment for destructive breast cancer
Summary. The authors report the method for the treatment of patients with local, including destructive, breast cancer, which consists in complex (palliative) treatment with the use of regional selective intra-arterial polychemotherapy and tumor cryoablation. The obtained findings demonstrated the advantages of this method vs. the traditional methods of treatment of this disease.
Key words: destructive forms of breast cancer, complex palliative treatment, radiation therapy.
2013, vol XXI, # 2, page 165
G.V. Bondar, Yu.I. Yakovets, Yu.V. Dumanskyy, N.H. Semykoz, V.KH. Basheyev, M.V. Bondarenko, A.Yu. Kyyashko, I.V. Sovpel
Treatment for local inoperable rectal cancer using regional intra-arterial chemotherapy
Summary. Based on the clinical material it is shown that immediate and long-term results of treatment of 98 patients with inoperable local rectal cancer were improved due to the use of regional intra-arterial chemotherapy according to the original protocol. This allowed reduction of post-operative mortality from 12,0 % (controls) to 2,1 %.
Key words: inoperable local rectal cancer, intra-arterial regional chemotherapy.
2013, vol XXI, # 2, page 166
Yu.K. Vivcharenko, I.YE. Kryzhanivska, I.Yu. Kostinskyy, P.F. Dudiy, I.M. Ostapyak, I.V. Boyko, S.S. Tsybran, R.M. Syrotynskyy
The tactics of treatment for superior vena cava syndrome in Ivano- Frankivsk Regional Clinical Cancer Hospital
Summary. The authors present the tactics of treatment for superior vena cava syndrome (SVCS) at various forms of malignant tumors in Ivano-Frankivsk Regional Clinical Cancer Hospital. It was shown that application of this tactics (the sequence of radiotherapy and chemotherapy) can improve the efficacy and quality of inductive treatment (elimination of SVC syndrome) in this group of patients as well as allow to deliver adequate radiation therapy to the patients with various tumor processes.
Key words: superior vena cava syndrome, small cell lung cancer, non-small cell lung cancer, polychemotherapy, distant radiation therapy, fractionation, accompanying therapy.
2013, vol XXI, # 2, page 170
G.V. Hatskevych, Y.H. Tarutyn, E.V. Tytovych
Systematization, archiving, and use of dosimetry information in radiation therapy
Summary. The authors report main principles of systematization and storage of dosimetry information in radiology hospitals. The problems of reception and use of dosimetry information to promote updated techniques of radiation therapy as well as application of this information at monthly quality assurance of the equipment are discussed. The recommendations based on the experience of RSPC OMR named after M.M. Alexandrov are given.
Key words: radiation therapy, dosimetry information, systematization, storage, application.
2013, vol XXI, # 2, page 171
V.M. Demchenko, I.V. Sokur, M.L. Kovalskyy, M.M. Lankyn, I.M. Hayday, I.S. Redko, V.I. Yefimov, YE.S. Kobelchuk
Application of magnetic resonance imaging to staging and assessment of efficacy of pre-operative chemoradiation therapy for local rectal cancer
Summary. The authors describe the capabilities of magnetic resonance imaging (MRI) used to assess the process dissemination. This allows correct staging of rectal cancer and choice of the necessary pre-operative radiation or chemo-radiation therapy. MRI also allows assessment of the degree of the tumor regression after pre-operative chemoradiation therapy for local rectal cancer.
Key words: assessment of rectal cancer dissemination, magnetic resonance imaging, chemoradiation therapy.
2013, vol XXI, # 2, page 173
E.A. Domina, V.S. Ivankova
The peculiarities of application of neutron radiation in radiation oncology
Summary. The role and significance of various energies of neutron radiation in radiation oncology are shown. The experience of application of neutron therapy suggests that most effectively it can be used to overcome resistance of the tumors of various locations. The article is devoted to the memory of outstanding scientists who contributed greatly to implementation, organization, and development of neutron therapy in Ukraine. It also covers the prospects of neutron therapy Key words: neutron radiation, radiation therapy, radiation oncology, neutron-capture therapy.
2013, vol XXI, # 2, page 175
O.O. Yehorov
Magnetic resonance imaging in women after organ-preserving treatment for precancer and initial stages of endometrial cancer
Summary. Investigations of the state of placenta in 40 women after organ-preserving treatment for precancer and initial stages of endometrial cancer demonstrated that magnetic resonance imaging was a highly effective method of diagnosis of the state of placenta and allowed to reveal the signs of fetoplacental dysfunction in this category of patients.
Key words: pregnancy, magnetic resonance imaging, placenta, endometrial cancer.
2013, vol XXI, # 2, page 176
V.S. Ivankova, L.M. Baranovska, O.M. Ivankova, N.P. Dotsenko
The role of hepatoprotectors in chemoradiation therapy for local breast cancer
Summary. The authors describe the role of hepatoprotectors Hepasol Neo 8% and Hepabene in chemotradiation therapy (CRT) of patients with local breast cancer (BC). The study involved 27 BC patients who developed the signs of liver failure during the course of CRT. The findings of the research suggest a more pronounced hepatoprotection effect of Hepasol Neo 8% which effectively contributed restoration of the normal level of main biochemical parameters of the blood serum and fast rehabilitation of the patients.
Key words: breast cancer, chemoradiation therapy, hepato-protectors.
2013, vol XXI, # 2, page 178
I.S. Ivankova, I.I. Smolanka, I.Yu. Sklyar, O.M. Ivankova, L.M. Baranovska, O.Yu. Stolyarova, O.F. Lihirda, M.I. Krotevych
The ways of improving efficacy of treatment for primarily inoperable breast cancer
Summary. The purpose of the work was to improve the efficacy of multimodality treatment for primarily inoperable breast cancer. Multimodality treatment was administered to 74 patients with local primarily inoperable IIB-IIIB breast cancer. Thirty-six patients (main group) were administered multimodality treatment against a background of radiomodification with fluorpyrimidines. The controls (38 patients) were delivered 4 courses of neoadjuvant polychemotherapy according to FAC protocol (cyclophosphan 500 mg/m2, 5-fluoruracil 500 mg/m2, doxorubicin 50 mg/m2), followed by a course of distant radiation therapy.
The results of treatment were more pronounced in patients from the main group. The indices of relapse-free survival tended to increase in patients of this group.
Key words: breast cancer, chemoradiation therapy, radiomodifiers, fluorpyrimidines, relapse-free survival.
2013, vol XXI, # 2, page 181
V.S. Ivankova, G.M. Shevchenko, T. V. Khrulenko, L.M. Baranovska, V.T. Perepechkina, G.V. Galyas
Investigation of early local toxicity of brachytherapy for cervical cancer using high-energy gamma-therapy unit Gyne Source
Summary. Conservative treatment was administered to 70 patients with IIB-IIIB cervical cancer (T2b-3bN0-1M0) with the purpose to improve the quality of combination radiation therapy according to the international standards using the developed techniques of complex radiation therapy considering individual planning of 60Co (HDR) brachytherapy. Efficacy of radiation therapy was assessed by the tumor focus regression and degree of local radiation reactions in the "critical organs". Toxic effects of treatment in the investigated patients did not differ in the number and degree from those in the controls and did not exceed grade II.
Key words: cervical cancer, 60Co (HDR) brachytherapy, combination radiation therapy.
2013, vol XXI, # 2, page 184
V.S. Ivankova, H.M. Shevchenko, T. V. Khrulenko, L.M. Baranovska, T. V. Skomorokhova, I.P. Mahdych, M.I. Paliy
The experience of conformal radiotherapy of locally advanced forms of cervical cancer
Summary. The Department of Radiation Oncology, National Cancer Institute, studies optimization of combined radiation therapy (CRT) for locally advanced cancers of the cervix (LACC). CRT was performed in 70 patients with stage IIB IIIB (T2b-3bN0-1M0) cervical cancer aged 29-70. Effective methods of complex conservative treatment of patients with LACC were worked out. Then the system of choosing the best mode of carrying out with the help of mathematical modeling, the correct, individual planning, precise implementation of the planned program of irradiation was used. To prevent toxic effects increase through the use of high-energy gamma-therapy units, a compbing of preventive megures, including drug presentia was taken. Toxic effects of treatment on their number and degree of symptoms between groups of patients did not exceed the second degree. The immediate results of CRT indicate that statistically significant differences in the response of the tumor and the reactions of the critical organs in patients of the groups who received brachytherapy for high-energy setting (HDR BT) by developing a method in comparison with the control was observed. However, there is a clear tendency to increase the regression group II patients with relatively radioresistant forms of LACC who underwent conformal external beam radiotherapy up to a total of 45 - 50 Gy followed by HDR BT single focal dose of 7 Gy, which is the result of amplification of the destructive effects of ionizing radiation on the high voltage tumor target.
Key words: cervical cancer, conformal radiotherapy, brachytherapy, the planning system of the course of irradiation.
2013, vol XXI, # 2, page 188
V.P. Ivchuk, L.V. Vintsevych, O.O. Yudko, N.A. Yefremova, L.M. Synyushkina
The peculiarities of planning and radiation therapy for stage I-III bladder cancer on a linear accelerator
Summary. The data on radiation treatment of 39 patients with stage I-III bladder cancer using a linear accelerator according to an individual radical program are presented. It is shown that conformal irradiation improves the efficacy and quality of the treatment, reduces radiation exposure to adjacent critical organs thus reducing the amount and degree of manifestation of radiation reactions and lesions.
Key words: bladder cancer, conformal radiation, radiation load.
2013, vol XXI, # 2, page 190
I.M. Kikhtenko, M.I. Khvorostenko, Yu.M. Khvorostenko
Treatment of hypothyroidism with ultralow frequency electromagnetic field
Summary. New special physical quantity, effective tissue dose of electromagnetic radiation, allows to plan the degree of correction of thyroid gland hypofunction and quantitatively assess its Results.
Key words: new special physical quantity, effective tissue dose of electromagnetic radiation, unit.
2013, vol XXI, # 2, page 193
Ya.V. Kmetyuk, H.O. Kurylo, O.V. Safronova, T.V. Udatova, T. H. Pidlubna, Yu.M. Kisil
Assessment of local toxicity manifestations at 3D conformal radiation therapy and IMRT at irradiation of small pelvis tumors
Summary. The advantages of IMRT were assessed vs. 3D conformal radiation therapy. Dose load to the bladder and rectum, manifestations of radiation cystitis and rectitis were evaluated. The findings of IMRT investigation allow to decrease the dose to the critical organs, which results in reduction of the frequency of radiation reactions.
Key words: 3D-conformal radiation therapy, intensity modulation radiation therapy, dose load, radiation therapy toxicity.
2013, vol XXI, # 2, page 195
O.V. Kovtunenko, M.I. Khvorostenko, I.S. Shponka, S.M. Tymchuk, D.V. Bereznyuk, O.V.Poslavska, I.M. Kikhtenko, Yu.M. Khvorostenko
The analysis of parameters of expression of vascular endothelial growth factor in patients with oropharynx cancer undergoing radiochemotherapy
Summary. The role of vascular endothelial growth factor (VEGF) is shown in the development of oropharynx cancer. A direct correlation between the increased expression of VEGF and a positive response to chemoradiotherapy (p = 0.004, r = 0.346) was revealed. The number of cases of squamous cell carcinoma of the oropharynx with high angiogenic activity is 1.7 times higher among the tumors that responded positively to chemoradiotherapy than those that responded negatively. Key words: vascular endothelial growth factor.
2013, vol XXI, # 2, page 199
A.Ye. Kryzhanivska, O.V. Dorosh, V.M. Halandzhiy, L.F. Zhyvetska
Chemoradiation therapy in treatment of patients with ІІВ cervical cancer
Summary. The authors present the experience of chemoradiation therapy application in patients with IIB cervical cancer. At combination of radiation with cisplatin and 5-fluo-ruracil in radiomodifying doses, 5-year relapse-free survival was 42 % , 5-year total survival was 48 % . Only in 6 % of patients who died before 5 years the death was caused by distant metastases. The most frequent cause of death was relapses in the small pelvis, which made 67.5 % of all relapses.
Key words: cervical cancer, radiation therapy, chemotherapy, cisplatin, 5-fluoruracil.
2013, vol XXI, # 2, page 201
G.V. Kulinich
Cardiac complications of radiation therapy to the chest organs in cancer patients: the problems of early diagnosis, follow-up and rehabilitation.
A case discussion
Summary. The paper deals with early diagnosis, classification, characteristics of observation and rehabilitation of cardiac complications of radiation therapy to the chest in cancer patients. The original findings show the character and range of complications in the cardiovascular system at radiation therapy both using a gamma-therapy unit and a linear accelerator. The questions of development of standards of diagnosis and treatment of cardiac complications of radiation therapy are discussed. A case is described.
Key words: radiation therapy, cardiac complications, chest tumors, diagnosis, classification, rehabilitation.
2013, vol XXI, # 2, page 204
S.M. Luchkovskyy, R. M. Zelinskyy
Narrow beam dosimetry
Summary. Application of new methods of the dose delivery such as IMRT ^intensity modulation radiation therapy), IGRT (image-guided radiation therapy), SRS (stereotaxic radiosurgery) require the use of beams less than 3 x 3 cm2. Such beams are termed narrow and require special attention when performing dosimetry and dose calculation, because this can cause to considerable over-irradiation of the patients. Literature analysis and our measurements demonstrated that optimal detectors for supporting dosimetry of narrow beams were diode detectors.
Key words: dosimetry, narrow beams, output coefficient, IMRT, CyberKnife, radiosurgery.
2013, vol XXI, # 2, page 207
O.L. Lyanna, H. V. Dolhikh, M.I. Khvorostenko, V.I. Chorna, O.Z. Brazaluk
Comparative assessment of cysteine proteinases activity (calpains and catepsins) in biological fluids of the patients with papillary thyroid carcinoma
Summary. The authors investigated the dynamics of activity of cysteine proteinases (calcium-dependent calpaines and lysosomal catepsins) in biological fluids (blood plasma and urine) in patients with papillary thyroid carcinoma. Increased activity of the investigated enzymes the character of which depended of the term of observation and stage of the treatment was administered, which can be considered nonspecific protective reaction to carcinogenesis, tumor invasion and/or delivered therapy.
Key words; cysteine proteinases, calpains, catepsins, papillary carcinoma, thyroid gland.
2013, vol XXI, # 2, page 211
I.I. Mynaylo
Individualization of radiation therapy in patients with squamous cell lung cancer
Summary. The work deals with development of the model of prospective individual prognosis of the tumor response to radiation therapy with determining the prognostic class of every new patient. A new approach to solving this task was proposed: to work out a method of determining individual tumor radiosensitivity considering the fact that the only absolute criterion of the tumor radiosensitivity is the degree of its response to radiotherapy.
Key words: radiation therapy, lung cancer, individual prognosis, radiosensitivity.
2013, vol XXI, # 2, page 212
I.I. Mynaylo, N.A. Artemova
Modern high technology radiation therapy
Summary. Creation of highly effective departments of radiation therapy equipped with modern radiotherapy facilities, qualified medical and technical staff using up-to-date methods of radiation therapy will allow to improve the results of cancer treatment. Realization of all tasks can expand the possibilities of radiation therapy and allow to answer the needs of cancer patients in the means of radiation therapy.
Key words: radiation therapy, modern technologies.
2013, vol XXI, # 2, page 216
D. V. Okuntsev, N.Y. Krutylyna, Al-Akva Abdul Mazhyd, L. B. Parkhomenko
The technique of three-dimensional (3D) planning of postoperative radiotherapy for T1-2N0M0 breast cancer
Summary. The present study was performed with the purpose to work out a technique of conformal three-dimensional (3D) radiotherapy planning of postoperative radiotherapy for patients with stage I-II breast cancer using up-to-date diagnostic and radiotherapeutic equipment of Republican Medical Center for Oncology and Medical Radiology named after N.N. Aleksandrov. The characteristic of 65 patients with stage I-II breast cancer is given, the technique of pre-radiation preparation and irradiation is described in detail.
Key words: breast cancer, radiotherapy planning, confor-mal three-dimensional radiation therapy.
2013, vol XXI, # 2, page 219
M.N. Petkevych, E.V. Tytovych, I.G. Tarutyn, A.V. Parchaykyna
Introduction of RapidArc technique into clinical practice of SI "RSP Centre of Oncology and Medical Radiology named after N.N. Alexandrov".
Aspects of planning
Summary. Theoretical aspects of treatment planning using RapidArc are featured Comparative analysis of planning methods, such as RapidArc, IMRT and 3DCRT was done. Several clinical examples with the use of RapidArc planning technology are given.
Key words: radiotherapy, treatment planning, RapidArc, contouring, multileaf collimator.
2013, vol XXI, # 2, page 221
V.F. Pochernyayeva, T.O. Zhukova, L.M. Vasko, L.O. Lymar
Treatment and prevention of hepatotoxic complications at radiochemotherapy
Summary. The mechanisms of hepatotoxic complications development during radiochemotherapy are analyzed. Clinical manifestations of radiochemical damage to the liver, the criteria for evaluation and principles of diagnosis were defined. A program of accompanying hepatoprotective therapy, the use of which reduced the percentage of anticipated hepatotoxic reactions during radiochemotherapy, was worked out.
Key words: radiochemotherapy, correction, hepatotoxic complications.
2013, vol XXI, # 2, page 222
A.S. Savchenko, L.O. Haysenyuk, H.V. Kulinich, V.P. Lavryk
Characteristics of radiation complications in patients with Hodgkin's lymphoma and non-Hodgkin's lymphomas at irradiation using a linear accelerator
Summary. Comparative characteristics of clinical forms and the incidence of radiation reactions and lesions at irradiation of the chest using a linear accelerator and ROKUS-AM unit in blood cancer patients was done in the hospital of Institute for Medical Radiology.
Key words: radiation therapy, radiation lesion, linear accelerator, mediastinal irradiation, Hodgkin's lymphoma, non-Hodgkin's lymphoma.
2013, vol XXI, # 2, page 226
N.G. Semykoz, N.G. Kukva, O.A. Hrabovskyy, M.O. Lichman, V.N. Pashkov, E.A. Kudryashova
Advantages of 3D conformal radiation therapy in treatment of various satages of prostate cancer
Summary. The results of relapse-free survival and the incidence of radiation complications demonstrate that 3D conformal radiotherapy using a linear accelerator is a more effective and safer method of radiation therapy for prostate cancer than conventional irradiation on telegamma-units, as it allows delivery of a high dose to the tumor and reducing the probability of radiation complications in «critical organs.
Key words: prostate cancer, 3D conformal radiation therapy, relapse-free survival, radiation complications.
2013, vol XXI, # 2, page 228
N.G. Semykoz, A.O. Shumilo, T. V. Karpushyna, O.A. Hrabovskyy, N.A. Lichman
The results of combination therapy for local cervical cancer
Summary. Administration of the developed technique of combination treatment based on split course of combination radiation therapy (RT) against a background of neoadjuvant chemotherapy to 275 patients with stage II-III cervical cancer allowed to transfer an immobile tumor process to the respec-
table state in 46.9% of cases, which was followed by the uterus and appendages removal, while with traditional course of RT operability index was only 6.9% .
Key words: local cervical cancer, combination radiation therapy, multimodality treatment.
2013, vol XXI, # 2, page 230
V.V. Synayko
Post-operative radiation and chemoradiation therapy with Temozolamide in patients with grade III anaplastic gliomas
of the brain
Summary. Post-operative radiation (RT) or chemoradiation therapy (CRT) with Temozolamide promotes 5-year survival in 52.4 % of cases of anaplastic oligodendroglioma and oligoastrocytoma and in 39.3 % of cases of anaplastic astrocytoma. CRT (vs. RT) increases 5-year survival of the patients with anaplastic astrocytoma from 28.4 ± 9.5 % to 56.2 ± 15.7 % (p = 0.042).
Key words: grade III anaplastic glioma, post-operative radiation (chemoradiation) therapy.
2013, vol XXI, # 2, page 232
P.P. Sorochan, N.E. Prokhach, I.A. Hromakova, I.M. Kruhova, V.S. Sukhin
The role of cytokines in development of hematological and immune disorders at radiation therapy for uterine body cancer
Summary. The changes in hematological and immune parameters in patients with uterine body cancer were analyzed by the stages of the combined treatment. The role of cytokines (IL-2, IL-6 IL-10, TNF-6) in the development of hematologic and immune disorders was assessed.
Key words: cytokines, radiation therapy, cancer of the uterine body.
2013, vol XXI, # 2, page 234
N.Yu. Spizhenko, T.I. Chebotarova, V. I. Lysak, V.P. Vashchyshyn
Treatment of patients with prostate cancer using up-to-date techniques of radiation therapy
Summary. The use of up-to-date high-technology variants of radiation therapy in patients with prostate cancer, namely radiation therapy with intensity modulation radiation therapy (IMRT), IMRT with integrated boost (linear accelerator ELEKTA SYNERGY); IMRT in hypofractionation mode with dose escalation (CYBER KNIFE); IMRT using linear accelerator with successive boost using CYBER KNIFE, allows radical irradiation with higher total focal doses without complications and with a favorable prognosis.
Key words: prostate cancer, Cyber knife, stereo tactic radiosurgery, linear accelerator, intensity nodulation radiation therapy, dose escalation.
2013, vol XXI, # 2, page 236
V.S. Sukhin, O.M. Sukhina, V.P. Starenkyy
Efficacy of treatment for stage I-II uterus leiomyosarcoma
Summary. Retrospective analysis of the results of complex treatment for stage I-II uterus leiomyosarcoma was done. All patients were performed surgery, radiation therapy, and chemotherapy. The treatment efficacy was assessed by the short-term and long-term treatment Results. The difference in yearly survival of this group of patients depending on the disease stage was not revealed. The efficacy of complex treatment for stage I-II uterus leiomyosarcoma depended on the disease stage; the relapses occurred in 31.8% of cases of stage I and 50% of cases of stage II.
Key words: uterus leiomyosarcoma, relapses, treatment outcome.
2013, vol XXI, # 2, page 239
E.V. Tytovych, M.N. Petkevych, Y.G. Tarutyn, G.V. Gatskevych
Introduction of RapidArc technique into clinical practice of SI "RSP Centre of Oncology and Medical Radiology named after N.N. Alexandrov". Dosimetric aspects
Summary. The process of dosimetric data measurement and calculation for its application in algorithms of dose distributions optimization in treatment planning system Eclipse used for irradiation method RapidArc is discussed. Specific tests for quality control of multileaf collimator used in RapidArc irradiation is analyzed. Dosimetric verification of patient treatment plans for RapidArc is descripted.
Key words: radiotherapy, RapidArc, multileaf collimator, quality control, verification.
2013, vol XXI, # 2, page 241
N.V. Tyuyeva, V.H. Dubinina, O.V. Lukyanchuk, L.P. Antonova, V.T. Stoyan
The capabilities of differentiated approach to combination of distance radiation therapy and high-dose brachytherapy in patients with local cervical cancer
Summary. High-dose brachytherapy was performed under computed tomography control in 33 patients with cervical cancer (CC). The technique of combining distance and contact dose radiation therapy, based on up-to-date mathematical models, the experience of European and American hospitals, considering the tumor growth in a particular case was developed.
Key words: local cervical cancer, radiation therapy, high-dose brachytherapy, computed tomography.
2013, vol XXI, # 2, page 244
M.I. Khvorostenko, I.M. Kikhtenko, Yu.M. Khvorostenko
Prognostic significance of pre-operative radiation dose for the results of combination treatment for gastric cancer
Summary. The authors analyze the survival of the patients with gastric cancer after combination treatment depending on the dose of ionizing radiation delivered to the tumor before the surgery. The dose of 54-56 Gy vs. the generally accepted dose allowed to increase significantly 5-year survival at local tumor process.
Key words: gastric cancer, combination therapy, survival.
2013, vol XXI, # 2, page 245
O.A. Chernychenko, V.S. Sakalo, O.V. Shcherbyna, Yu.M. Bondarenko, P.H. Yakovlev, A.V. Sakalo, ZH. Adamets
The peculiarities of bone mineral density disorders in patients with local prostate cancer depending on hormone therapy protocol
Summary. The influence of various protocols of androgen-suppressive therapy on bone mineral density as well as influence on mineral metabolism in the bones of nonsteroid androgens (bicalutamide) in patients with prostate cancer were compared using x-ray osteodensitometry.
Key words: prostate cancer, osteopenia, osteoporosis, osteodensitometry, bicalutamid, diferelin, bilateral orchidectomy.
2013, vol XXI, # 2, page 247
V.A. Chornobay
Pharmacotherapy for relapses and metastases of cervical cancer: from fluorpyrimidines to target drugs
Summary. Nineteen percent of Ukrainian patients with cervical cancer present with generalized stages of the disease. Dissemination and progression of the process occur in 40-50% of the patients, 16% do not survive over a year after the diagnosis has been made. Administration of Topotecan, Gemzar, taxanes separately and by the protocols as well as in combination with target drugs allows to prolong the life span and improve its quality in this group of the patients.
Key words: relapsing and disseminated cervical cancer, pharmacotherapy.
2013, vol XXI, # 2, page 250
Т.D. Shchehlovska, V.L. Yakobchuk, T.A. Ratnikova, V. V. Filipchuk
The ways of optimizing radiation therapy in patients with cancer of the upper respiratory tract
Summary. The authors feature the stages of 3D conformal radiation therapy, namely IMRT, in patients with malignancies of the upper respiratory tract, including planning computed tomography, contouring, planning, irradiation, and clinical management.
Key words: 3D conformal radiation therapy, IMRT, immobilization, computed tomography, contouring, planning, treatment.
2013, vol XXI, # 2, page 253
O.O.Yudko
Monte Carlo calculation of backscatter factor for monoenergetic x-rays
Summary. Backscatter factors were calculated for mono-energetic x-rays (10-300 kev). Their dependence on the energy, field size, and thickness of the irradiated material was determined. Dose-depth distribution was established; analytical dependence of the dose on the target depth was revealed.
Key words: Monte Carlo simulation, backscatter factor, x-rays.
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We are proud to announce the annual scientific conference of young scientists with the international participation, dedicated to the Day of Science in Ukraine. The conference will be held on 20th of May, 2016 and hosted by L.T. Malaya National Therapy Institute, NAMS of Ukraine together with Grigoriev Institute for medical Radiology, NAMS of Ukraine. The leading topic of conference is prophylaxis of the non-infectious disease in different branched of medicine.
of the scientific conference with the international participation, dedicated to the Science Day, «CONTRIBUTION OF YOUNG PROFESSIONALS TO THE DEVELOPMENT OF MEDICAL SCIENCE AND PRACTICE: NEW PERSPECTIVES»
We are proud to announce the scientific conference of young scientists with the international participation, dedicated to the Science Day in Ukraine that is scheduled to take place May 15, 2014 at the GI “L.T. Malaya National Therapy Institute of the National academy of medical sciences of Ukraine”. The conference program will include the symposium "From nutrition to healthy lifestyle: a view of young scientists" dedicated to the 169th anniversary of the I.I. Mechnikov.
Ukrainian Journal of Radiology and Oncology
Since 1993 the Institute became the founder and publisher of "Ukrainian Journal of Radiology and Oncology”:
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S. P. Grigorjev