UJR 2015, vol XXIII, # 1
THE CONTENTS
2015, vol XXIII, #1, page 11
I. O. VORONZHEV
Kharkiv Medical Academy of Postgraduate Education
X-RAY DIAGNOSIS OF ASPIRATION SYNDROME AND ITS COMPLICATIONS IN INFANTS WITH PERINATAL IMPAIRMENT OF CENTRAL NERVOUS SYSTEM
Purpose. Improving diagnostic of aspiration syndrome (AS) in infants with perinatal injuries of central nervous system (cNS), by the way of the objectify severity of damage.
Materials and Methods. Analyzed data X-ray of the chest (cXR) in 87 patients, aged from birth to 1 year with diagnosis of hypoxic-ischemic and traumatic cNS injuries, aspiration syndrome and pneumonia. cXR performed using RUM-20M under these specifications: 100 mA, 44-46 kV, exposure to 0.02-0.04. The specific effective dose did not exceed 2.8 mkSv / MAC. To verify the diagnosis, all patients performed ultrasonography (USG) of the brain, cardiovascular system, with using Doppler echocardiography, as well as a complete clinical and laboratory examination. To confirm the traumatic CNS lesions in 20.7 % of the children performed magnetic resonance imaging (MRI) of the brain and spinal cord.
Results. The study shows that the most characteristic features of aspiration syndrome in these patients are: enrichment of lung pattern, development of pneumonia, atelectasis, and combination of them with respiratory distress syndrome. In this article we are describing the using of metric methods in plain roentgenology the diagnosis of AS severity on the calculation of the data of cardiothoracic index, displacement of the diaphragm and prevalence of focal shadows in the lungs. There was high correlation between the severity of the AS and individual performance, as well as indices to each other. The analysis allowed to identify and diagnosed first stage of AS severity in 40.2 % of the patients, 36.8 % — the second stage, and 23.0 % — third stage of AS severity.
Conclusions. The studies allowed to distribute aspiration syndrome in infants with perinatal CNS lesions with the radiometric data into three stages of severity of the enlargement of cardiothoracic index, degree of diaphragm displacement and the prevalence of focal shadows in the lungs.
Keywords: chest X-ray, aspiration syndrome, perinatal CNS injuries.
2015, vol XXIII, #1, page 18
V. I. KALASHNIKOV, R. YA. ABDULLAYEV, A. E. KOSTYUKOVSKAYA
Kharkov Medical Academy of Postgraduate Education
THE ROLE OF DUPLEX SCANNING OF MAJOR ARTERIES OF THE HEAD AND MAGNETIC RESONANCE IMAGING IN DIAGNOSIS OF STRUCTURAL HEMODYNAMIC DISORDERS IN MIGRAINE
Purpose. The aim of this study was to examine the state of the brain substance and cerebral hemodynamics using MRI and DS techniques in patients with different types of migraine paroxysms.
Materials and Methods. A comprehensive survey of 104 patients aged from 16 to 45 (41 men and 63 women) was carried out, including: 59 patients with migraine without aura (group 1) and 45 patients with migraine with aura (group 2). We studied the hemodynamics in the extracranial and intracranial arteries using ultrasonic instrument «Ultima PA» (RADMIR, Ukraine) and transcranial Doppler device «Angiodin» (BIOSS, Russia). MRI of the brain on devices «Magnetom Concerto» (Siemens, Germany) and Signa HDe (General Electric, USA) was performed.
Results. According to MRI, structural changes of white matter of the brain were found in 17 (28.8 %) patients in group 1 and 24 (53.3 %) patients in group 2. These changes were characterized by hyperintense on T2WI and predominantly izointense on T1WI foci, the size of which ranged from 3 mm to 12 mm. Most often these foci localized in the temporal (38.6 %) and frontal (31.4 %) lobes. In patients with migraine without aura vasospastic reactions dominated in the middle cerebral arteries.
Conclusions. In patients with migraine with aura, we detected marked hypoperfusion and asymmetry of the flow velocity in the middle cerebral and vertebral arteries, as well as increase in peripheral resistance in the middle cerebral arteries. The patients in both groups also had an excessive blood supply in external carotid arteries, superior ophthalmic veins, Rosenthal basal veins and straight sinus.
Keywords: duplex scanning, magnetic resonance imaging, cerebral hemodynamics, migraine.
2015, vol XXIII, #1, page 23
L. I. SIMONOVA-PUSHKAR1, N. I. SKLYAR2, V Z. GERTMAN1, L. V. BYELOGUROVA1, A. T. GONI SIMEHA1
1 SI «Grigoriev Institute for Medical Radiology, National Academy of Medical Sciences of Ukraine», Kharkiv
2 SI «Mechnikov Institute of Microbiology and Immunology, National Academy of Medical Sciences of Ukraine», Kharkiv
PECULIARITIES OF SKIN MICROBIOCENOSIS OF THE LABORATORY ANIMALS EXPOSED TO IONIZING RADIATION
Purpose. To study quantitative and qualitative shifts in microbial flora in local irradiation of intact skin.
Material and methods. The research has been done on 20 Wistar male rats divided into 2 equal groups, i.e. experimental and control ones. Experimental rats were X-ray irradiated on the skin area of the outer part of thigh with 80.0 Gy dose. Qualitative and quantitative composition of spontaneous microflora of the locally irradiated skin areas of rats and similar skin areas of non-irradiated control animals were compared with the aid of standard microbiological methods.
Results. The majority of experimental rats (60-70 % of experimental group) developed radiation ulcers in 14 days after irradiation, frequently with purulent discharge. At the same time in the experimental group of locally irradiated rats (as opposed to the control with intact skin), the titre of dissemination was raising on radiation ulcer surface during all period of observation and additional species composition of microflora was widening as well as its quantity characteristics were changing. Additional opportunistic and pathogenic, quite virulent microorganism species appeared and grew in number along with the development of destructive pathological processes in the skin. Conclusion. The rats with locally irradiated area of skin developed an increase of microbial dissemination and appearance of additional species of pathogenic and opportunistic microorganisms in the exposed area that proves affected bactericide properties of skin and decreased immunological reactivity of macroorganism.
Keywords: X-ray irradiation, radiation ulcers, skin microflora, rats.
2015, vol XXIII, #1, page 30
E. V KUZMENKO, G. V KULINICH, P. P. SOROCHAN, A. S. SAVCHENKO
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
ROLE OF TRANSFORMING GROWTH FACTOR TGF-β1 IN PATHOGENESIS OF MALIGNANT NEOPLASMS
Purpose. Estimation of dynamic of TGF-β1 cytokine level depending on stage and localization of neoplastic process.
Materials and Methods. The initial level of TGF-β cytokine in blood serum of 20 healthy people (control group) and 62 patients aged from 20 to 79 with different localization and stages of neoplastic process, i.e. Hodgkin’s lymphoma (n = 18), non-Hodgkin lymphoma (n = 8), lung cancer (n = 18), breast cancer (n = 18), was carried out. II stage was detected in 29 patients (46.8 %), III stage — in 12 patients (19.4 %), IV stage — in 21 patients (33.8 %). Cytokine TGF-β1 content in blood serum was estimated by means of DRG TGF-β1 ELISA (Germany) test system for enzyme multiplied immunoassay on Sunrise photometer.
Results. It has been established that the average level of TGF-β1 in tumor growth appeared to be significantly higher in comparison with control. The study of TGF-β1content depending on tumor location revealed some peculiarities. In lung cancer and breast cancer, TGF-β1 content was significantly different from control and it was twice higher than in Hodgkin’s lymphoma and non-Hodgkin lymphoma. TGF-β1content at II and IV stages of oncogenesis was 1.5-2 times higher in comparison with II stage of the disease.
Conclusions. Increase of TGF-β1content in peripheral blood is observed in tumor growth. It suggests activation of mechanisms of immune suppression in oncology patients. It is found that TGF-β1 level in peripheral blood depends on localization and stage of oncological process. In this case TGF-β1 level increases according to progressing of neoplastic process.
Keywords: TGF-β1, breast cancer, lung cancer, non-Hodgkin lymphoma, Hodgkin’s lymphoma.
2015, vol XXIII, #1, page 35
S. О. PONOMARENKO
Kharkiv Medical Academy of Postgraduate Education a comparative analysis of radiological study methods in stenosis of the spinal
CANAL OF the LUMBAR COLUMN
Purpose. Of the study was to determine ultrasound diagnostic criteria of stenosis of the lumbar region and capabilities of US in comparison with other radiological methods.
Materials and Methods. According to the purpose, 128 patients with the degenerative diseases of the lumbar spine were examined. Stenosis of the spinal canal was revealed in 48 people.
Results. On the basis of comparison of US findings, MRI data and clinical presentation of stenosis of the spinal canal, classification of stenosis of the spinal canal has been elaborated. The suggested classification is based on estimation of value of sagittal size and area of the spinal canal, measured by planimetric method by means of US at the level of intervertebral disk. Percentage ratio of moderate stenosis of the spinal canal was 44 %, insignificant — 33 % and severe — 23 % of patients.
The study of diagnostic capabilities of US in comparison with MRI and X-ray in stenosis of the spinal canal of the lumbar column has been conducted. Dysplastic stenosis was diagnosed in 12.5 % of cases. Degenerative stenosis was diagnosed in 42 people (87.5 %). In particular: 22.91 % — concentric stenosis (diminishing of all sizes); 37.5 % — lateral stenosis (reduction of frontal size and area of the spinal canal; the radicular canal was narrowed on the side of affection); central stenosis was diagnosed in 10.4 % of cases (it was characterized by diminishing of A-P dimension and area of the spinal column); 6.4 % of cases — foraminal stenosis; 10.4 % of cases — dislocation stenosis caused by spondylolisthesis.
Conclusion. US is considered to be an informative method of diagnosis of degenerative stenosis of the spinal canal (test sensitivity — 87.5 %). High specificity and exactness of US in visualization of location, directions and dimensions of hernias in lumbar osteochondrosis and stenosis of the spinal canal (88.5 % and 87.9 %) have been proven. The obtained findings suggest using of ultrasonography at stages of primary diagnosis of this pathology. Keywords: ultrasound diagnosis, lumbar spine, degenerative changes, intervertebral disc.
2015, vol XXIII, #1, page 40
L. YA. VASILIEV1, E. B. RADZISHEVSKA1,2, YA. E. VIKMAN1,2, A. M. NASONOVA1
1 SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
2 Kharkiv National Medical University
MATHEMATICAL ANALYSIS OF RESPONSE TO TREATMENT OF ONCOLOGY PATIENTS WITH DUE REGARD FOR POTENTIAL CARCINOGENIC EFFECT OF CHEMOTHERAPY AND FORMATION OF METACHRONOUS TUMORS
Objective. To clarify potential carcinogenic action of chemotherapy associated with one course of radiotherapy.
Materials and Methods. In order to conduct the research, electronic database containing information from 501 case records (194 case records of the patients with second tumors which appeared after treatment (DP group) in 3 years and more; 157 cases of the positive control group which included patients without second tumors, but with metastatic tumors (ЫТ group) and 150 cases where no adverse effects were observed in patients (NFc group) for more than 5 years).
Before direct analysis of response to the treatment, analysis of the data with due regard to stage, morphology, location and clinical course of the first tumor, clinical laboratory data concerning host state and other features of the first tumor and factors which were used in order to get rid of it, was carried out. The research was conducted by means of comparison of the definite data between the patient groups with second tumors, late metastatic tumors in patients without adverse effects after treatment of the first tumor.
Results. Potentially higher number of patients without adverse effects in 5 years and more after special treatment had neoadjuvant therapy in scheme of chemotherapy. Besides, in the patients of this group during treatment of the first tumor by means of chemotherapeutic agents, more severe involvement of the blood system was observed. In addition, the drugs which were used to treat patients of this group had higher emetogenic potential. It has been proved that use of antineoplastic antibiotics reduces the probability of formation of second tumors almost by half; in this case the most successful were effects of treatment according to cAF scheme in comparison with cAMF. Perhaps it suggests carcinogenic action of methothrexates.
It has been ascertained that among schemes of chemotherapy which do not contain anthracyclines the most effective was response to treatment according to scheme «F + leucovorin».
Action of anthracyclines is enhanced by platins: probability of formation of other types of cancer in chemotherapy without platinum is 0.58, without antineoplastic antibiotics — 1.16, without both groups of drugs — 1.88.
Conclusions. Мathematical approaches to analysis of medical data make it possible to obtain additional knowledge and to reveal dependence in the most severe current problems.
Keywords: metachronous tumors, chemotherapy, antineoplastic antibiotivs, involvement of the blood system, neoadjuvant chemotherapy.
2015, vol XXIII, #1, page 47
V. CARVARSARSKAYA, L. GREBINIK, N. BELOZOR, S. BASILAYSHVILI, T. BAKAI, N. MITRYAEVA, V. STARENKIY, V. STARIKOV
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine», Kharkiv
BLOOD SERUM VEGF CONTENT AS THE MARKER OF ANGIOGENESIS IN PATIENTS WITH LUNG CANCER
Objective. To reveal possible connection between blood serum VEGF content and clinicomorphological characteristics of the disease.
Material and methods. The study involved 37 patients with non-small-cell lung cancer aged from 40 to 72 who were undergoing treatment at SI Istitute for Medical Radiology of National Academy of Medical Sciences Kharkiv Regional cancer center and control group of 14 healthy patients. common clinical, morphological and radiological examination of all patients was carried out. Blood serum VEGF content was determined by means of enzyme multiplied immunoassay with the use of standard sets «Вектор-Бест» (Russia) before and after treatment. Results. Blood serum VEGF content was elevated in 75.6 % patients with NScLc before treatment. The connection between VEGF expression and such clinicomorphological characteristics as stage of disease, degree of malignancy and involvement of lymph nodes was revealed.
Conclusion. The analysis of expression level of serum VEGF in patients with non-small-cell lung cancer showed the possibility of use of this marker for monitoring of chemoradition therapy.
Keywords: radiotherapy, vascular endothelial growth factor (VEGF), angiogenesis, non-small-cell lung cancer.
2015, vol XXIII, #1, page 51
T. S. GOLOVKO, V S. IVANKOVA, O. A. BAKAY
The National Cancer Institute, Kiev
APPLICATION OF ELASTOGRAPHY TO MONITOR EFFECTIVENESS OF CONSERVATIVE TREATMENT OF CERVICAL CANCER
The aim of this work was to study the possibilities of elastography to monitor the effectiveness of conservative treatment of cervical cancer.
Materials and Methods. Were examined using elastography 48 patients with cervical cancer ІІЬ-IVa stage before, during and after the course of combined radiotherapy. Control group included 30 healthy women.
Results. Investigations has been demonstrated that the differences in elasticity of cervix in the norm and malignant pathologies are evidently reflected in elastographic images. In the norm cervix in all cases remained elastic and was mapped predominantly green, while scanning of cervical cancer, characterized by a high degree of rigidity, on elastograms prevailed blue coloring. Among this it was established, that changes in cervix elasticity, caused by chemo-radiotherapy, were also detected by elastography. Just after stage 1 of the chemo-radiotherapy distribution of elastogram types shifted towards less severe. After the treatment finishing elastograms were similar to that in non-malignant processes with dominated elastic types, but in a 25 % inflexibility was enhanceable, that reflected the large number of rigid post-radiation fibrous inclusions in the cervix, having high inflexibility. In recurrent cervical cancer distribution of elastographic types was similar to that seen in the primary tumor.
Conclusions. Research results prove expedience using method, availability, low cost and safety.
Keywords: elastography, ultrasound diagnosis, monitoring of radiation therapy, cervical cancer.
2015, vol XXIII, #1, page 57
I. A. HROMAKOVA, P. P. SOROCHAN, N. E. PROHACH, I. S. HROMAKOVA, I. M. KRUGOVA
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
HEMATOLOGICAL, IMMUNOLOGICAL AND ENDOCRINE DISORDERS IN PATIENTS WITH HYSTEROCARCINOMA WITH INSULIN RESISTANCE OF DIFFERENT Degree IN COMBINED ANTINEOPLASTIC TREATMENT
Purpose. To estimate peculiarities of hematological, immunological and endocrine disorders in combined treatment of patients with hysterocarcinoma with insulin resistance of different degree.
Materials and Methods. The study involved 28 patients with hysterocarcinoma of I-III stages with histologically diagnosed adenocarcinoma. All patients underwent panhysterectomy and postoperative course of distant gamma-therapy by means of «РОКУС-АМ» device through the method of divisional fractionation. The total dose was 40-45 Gy on A and P points. The examination was carried out at 3 stages: before treatment, after surgery and after radiotherapy. Immune status indices were studied: lymphocytes subpopulation (CD3+, CD8+, CD19+); neutrophil phagocytic rate; levels of circulating immune complexes and immunoglobulins A, M, G. Hematological indices were defined by means of analyzer SF-3000 «SYSMEX». Levels of serum insulin and cortisol were estimated through immunoenzyme method. Degree of insulin resistance was defined according to НОМА index. Levels of melatonin excretion with urine were estimated on the basis of the reaction with ortho-phthalic aldehyde.
Results. Specific changes of immune and hematological indices, levels of insulin, cortisol and melatonin at stages of combined treatment in patients with insulin resistance of different degree have been revealed.
Conclusions. After radiotherapy, carried out for patients with hysterocarcinoma with insulin resistance, absolute number of leukocytes, lymphocytes and thrombocytes is lower than in patients without insulin resistance. Thrombocyte rate after treatment depended on degree of insulin resistance and was lower in patients with initially high insulin resistance. In all patients increase of relative count of eosinophils was observed after radiotherapy. Higher relative and absolute count of eosinophils is observed in patients with high insulin resistance. Patients with high insulin resistance after radiotherapy have higher amount of erythrocytes and higher level of hemoglobin in comparison with patients without insulin resistance or with low insulin resistance. Patients with high insulin resistance had higher level of cortisol at all stages of treatment. Melatonin excretion in these patients was decreased in case of surgical or radiation therapy and after it day hormone excretion was almost half as high as this index in groups without insulin resistance or with low insulin resistance. Auxiliary treatment directed to limit negative influence of radiotherapy is reasonable for patients with insulin resistance. Taking into account a wide range of immunomodulatory features of melatonin and significant decrease of its level in patients with insulin resistance, use of melatonin as an element of auxiliary treatment scheme of oncology patients can be effective.
Keywords: hysterocarcinoma, insulin resistance, immune status, cortisol, melatonin, radiotherapy.
2015, vol XXIII, #1, page 65
M. M. TKACHENKO, P. O. KOROL
A. A. Bogomolets National Medical University, Kiev
ROLE OF BONE SCINTIGRAPHY IN DIAGNOSTIC SCREENING OF PATIENTS WITH ENDOPROSTHESIS REPLACEMENT Of HIP JOINTS
Purpose. Aim. Learn the role of bone scintigraphy in the diagnostic dynamic observation of patients with osteoarthrosis in hip joints.
Material and methods. On the basis of National Medical University. A. A. Bogomoletz by bone scan were examined 65 patients with osteoarthrosis of the hip joints between the ages of 54 to 75 years. Bone scintigraphy was performed on scintillation gamma camera in a static mode after intravenous injection of 99mTc-pyro-phosphate 550-770 MBq activity.
Results. In all patients, the first diagnostic group and in 10 (44%) patients of the second group on postoperative scan in the projection of prosthetic joint component, the percentage of accumulation of the radiopharmaceutical was +15 - +45%. The functional state of the hip joint prosthesis after by Harris hip score improved from 39 ± 4 to 77 ± 5. In 13 (56%) patients of the second diagnostic group 6 months after prosthesis in quantifying scintigrams, the percentage of inclusion of the indicator in the areas of increased accumulation of the components of the hip joints was +180 - +260%. The functional state of the hip joint prosthesis after by Harris hip score deteriorated slightly from 39 ± 4 to 36 ± 5. These patients were encouraged to revision hip replacement.
Conclusions. Method bone scan is a modern sensitive method for the study of the criteria of operability of patients with hip arthroplasty. Diagnostic bone scan is appropriate to include in the clinical program required diagnostic examinations of patients with hip arthroplasty.
Keywords: bone scintigraphy, endoprosthesis replacement, hip joints.
2015, vol XXIII, #1, page 68
N. O. ARTAMONOVA1, A. E. GORBAN2, G. V. KULINICH1, YU. V. PAVLICHENKO1, L. I. ZAKRUTKO2, L. M. NOVGORODSKA2, L. G. BILAN2
1 SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine», Kharkiv
2 Ukrainian Scientific Center of Medical Information and Patent License of Ministry of Healthcare of Ukraine, Kiev
SCIENTOMETRIC ANALYSIS OF MEANS OF SCIENTIFIC COMMUNICATION IN ONCOLOGY
Purpose. Srientometric assessment of innovation resources according to oncology problems.
Materials and Methods. Innovation resources for 2009-2014 such as leaflets, guidelines, register of field innovations and medical scientific fora as well as patents for inventions and utility models, have been analyzed.
Results. Quantitative indices of intensity of process of guidelines and leaflets elaboration on annual and subject basis have been estimated. The analysis of a structure of scientific communication in oncology has made it possible to establish distribution of guidelines and leaflets, especially in 2011, and for the last two years the tendency of increase of quantity of leaflets concerning treatment of oncology patients is observed. Developers of guidelines and its subject were analyzed. The analysis of patent statistics in order to obtain classification of them according to treatment methods, diagnosis, prognosis and prevention of oncological diseases was carried out.
Conclusions. It has been established that in subject structure of the innovations in oncology for 2009-2014, offers concerning implementation gain the lead, according to new methods of treatment (54.0 %), diagnosis (15.0 %) and prevention (15.0 %) of oncological diseases. Increase of quantity of innovations has been ascertained suggesting importance of this innovation means which serves as marketing communication in order to improve effectiveness of oncological diseases control. There are more than 20 state institutions including 7 medical higher education institutions, 3 academies of postgraduate education and National Cancer Institute of Ministry of Health, 4 scientific institutions of the National Academy of Medical Sciences among the patent holders of utility models.
Keywords: oncology, scientometrics, communication means, patents, guidelines, innovations, fora.
2015, vol XXIII, #1, page 73
N.G. SKOROBOGATOVA, N.E. UZLENKOVA
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine», Kharkrv
ВONE MARROW-DERIvED MESENCHYMAL STROMAL CELLS: BIOLOGICAL AND RADIOBIOLOGICAL ASPECTS OF RESEARCH
The review analyzes classic and modern data on biology and radiobiology of mesenchymal stromal cells (MSCs) derived from bone marrow (BM) of an adult organism have been. Radiosensitivity of the colony-forming units of fibroblasts (CFUf), including mesenchymal stem cells (MSCs) and their descendants with different proliferation and differentiation potential, was considered. A dose-dependent decrease in the CFUf number after irradiation was shown. The presence of highly radiosensitive population of MSCs in the total pool of BM stromal cells was proved. In conclusion, the questions were raised concerning the necessity of studying the particularities of radiation-induced damage in MSCs and prospects for development of radioprotection agents targeted at BM stroma recovery as hematopoietic «niche» and saving the reserve of multipotent BM MSCs in the irradiated organism.
Keywords: mesenchymal stromal cells, colony-forming units of fibroblasts, bone marrow, radio-sensitivity.
2015, vol XXIII, #1, page 80
I. SAFONOVA
Kharkiv Medical Academy of Postgraduate Education
POSTNATAL CLINICAL OUTCOMES IN DIFFERENT ULTRASONOGRAPHIC OPTIONS OF ABNORMALITIES OF FETAL URINARY SYSTEM: LITERATURE REVIEW AND ANALYSIS OF CASE SERIES
The article contains an analytical review of the literature about postnatal clinical significance of fetal anomalies of the urinary system (US), and an analysis of ultrasound images and postnatal outcomes in 18 cases with fetal US anomalies detected after 22 gestational weeks. The ultrasound criteria for predicting clinical postnatal outcome with fetal uropathies were designed. Sonographic abnormalities and their combinations which were associated with different postnatal results, including those that require postnatal monitoring were found. About a half of congenital malformations of the fetal US are detected in the perinatal period, after routine scan, as they have a late manifestation of ultrasound findings. This confirms the view of the need to routinely scan in the third trimester of pregnancy. Keywords: fetus, ultrasound, abnormalities of the urinary system, perinatal outcome, postnatal monitoring.
2015, vol XXIII, #1, page 84
L. I. SIMONOVA-PUSHKAR, V. Z. GERTMAN, L. V. BILOGUROVA
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
BACKGROUND AND PROSPECTS OF USE OF PHOTODYNAMIC THERAPY IN DIFFERENT FIELDS OF MEDICINE AT THE PRESENT STAGE (LITERATURE REVIEW)
This review provides information concerning history of photodynamic effect discovery, searches for photosensitive compounds, subsequently called photosensitizers, and highlights the first attempts to use the method of photodynamic therapy in medicine. Current understanding of mechanisms of photodynamic action on living cells is further considered as well as the data on use of the method of photodynamic therapy in different non-oncology fields of medicine are given.
Keywords: photodynamic therapy, photosensitizers, mechanisms of action, use in medicine.
2015, vol XXIII, #1, page 92
N. V KRASNOSELSKIY1,2, A. N. BELIY1,2, E. N. KRUTKO1, A. V. PANOV1, A. V. MOVCHAN1
1 SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine», Kharkrv
2 Kharkiv national medical University
PECULIARITIES OF DIAGNOSIS AND TREATMENT OF A LARGE FOREIGN BODY OF INTERMEDIATE BRONCHUS
The article describes the case of a foreign body of intermediate bronchus in a 52 years patient without anamnestic indications of aspiration. The patient for a long time (25 years) with chronic bronchitis, frequent right-sided pneumonias, empyema of pleura (2007) in history. When fibrobronchoscopy was found «old» foreign body, obstructed the lumen of the intermediate bronchus, endoscopical removal was twice failed. Only thoracotomy with bronchotomy allowed to remove solid foreign body.
Keywords: foreign body of bronchus, fibrobronchoscopy, bronchotomy.
2015, vol XXIII, #1, page 95
N. O. ARTAMONOVA, Y. V PAVLICHENKO, O. S. KRYVULYA
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine», Kharkrv
ADVANCED RADIOLOGICAL METHODS OF DIAGNOSIS OF DISSEMINATION OF TUMORS (ABSTRACT REVIEW)
Presented review of abstracts highlights achievements in modern radiology based on the materials of international publications. The review includes articles of the leading scientific journal «Clinical Nuclear Medicine» for recent years on a wide range of issues of diagnosis of metastases, in particular with the use of PET/CT and other methods for the detection of bone metastases, metastases of breast cancer, lung cancer, thyroid cancer and other.
Keywords: diagnostic radiology methods, bone metastases, metastases, breast cancer, lung cancer, cancer of the thyroid gland.
2015, vol XXIII, #1, page 116
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