UJR 2018, vol XXVI, # 4
2018, vol XXVI, # 4, page 231
V. A. PRYLYPKO, O. O. PETRYCHENKO, M. N. MOROZOVA, I. V. BONDARENKO
SI «National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine», Kyiv
RESOURCE POTENTIAL OF MEDICAL SUPPORT OF RNPP OBSERVATION ZONE POPULATION
The paper deals with the data analysis focused on medical support of the population living in Rivne NPP observation
zone over time. The study was carried out applying statistical data provided by regional information and analytical
centers of medical statistics of Rivne and Volyn regions along with data obtained from the study of public opinion
concerning negative components of the quality of medical care and their improvement.
The performance of health care institutions in Rivne NPP observation zone is determined by a complex of factors,
one part of which lies in the area of social and economic problems (impoverishment of the population), and another
one in the area of the implementation of articles of legislative documents of the medical reform.
Keywords: NPP observation zone, healthcare institutions, resource potential, public opinion.
2018, vol XXVI, # 4, page 239
L. I. SIMONOVA, V. Z. HERTMAN, O. S. PUSHKAR, N. V. LIAKHOVSKA
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
PHOTODYNAMIC THERAPY IMPACT ON ENDOGENOUS ANTIMICROBIAL MECHANISMS IN TREATMENT OF INFECTED RADIATION SKIN INJURIES
Purpose. Study of photodynamic effect on endogenous antibacterial protection indices (nitric oxide and enzyme
myeloperoxidase) in animals with infected radiation ulcers.
Material and Methods. The study enrolled 90 male rats with local X-irradiation of the hip skin at a dose of
85.0 Gy. When the signs of a radiation ulcer (day 7) appeared, the irradiated area was infected with Pseudomonas
aeruginosa strain. One day later, the experimental group animals (30 rats) with the infected radiation ulcers were
exposed to photodynamic therapy by means of Barva-LED/630 device with a methylene blue photosensitizer. In
blood serum, the total content of stable metabolites of nitric oxide (NO) and myeloperoxidase (MPO) activity in
neutrophils was assessed by cytochemical method.
Outcomes. It has been established that the development of “pure” ulcer was accompanied by an increased level
of NO metabolites in blood serum (30–40% out of normal) over the entire observation period. Infection of the
radiation ulcer signifcantly increased the release of metabolites into blood serum (80%). After PDT, a steady
decrease to normal values was observed. At the same time, the development of MPO defciency in neutrophils
associated with radiation ulcer was noted. In the case of “pure” ulcer, enzyme activity was decreased (by 20–35%)
during 30 days, however by the end of the experiment (day 45) it was restored.
When the ulcer was exposed to infection, there was a progression of decreased activity of MPO by 1.5–2 times,
which was signifcantly lower than in just irradiated rats and normalization of the parameters was absent for the
entire observation period. In animals with an infected ulcer which was exposed to PDT, MPO activity was restored
to normal values almost immediately after elimination.
Conclusions. Applying PDT for antimicrobial therapy of infected radiation skin lesions in experimental animals
resulted not only in the destruction of the introduced microbes, but also contributed to the activation of its own
endogenous antimicrobial mechanisms in the form of normalization of the level of nitric oxide in serum and the
activity of myeloperoxidase in neutrophils, indicating the restoration of their functional properties.
Keywords: Photodynamic therapy, Radiation ulcers, Pseudomonas aeruginosa, nitric oxide, myeloperoxidase.
2018, vol XXVI, # 4, page 245
L. YA. VASILIEV 1, H. V. KULINICH 1, YE. B. RADZISHEVSKA1, 2
1 SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
2 Kharkiv National Medical University
LONG-TERM EFFECTS OF RADIONUCLIDE THERAPY IN THYROID CANCER TREATMENT (FIRST INFORMATION STATEMENT)
Purpose. To make an analysis of long-term oncological effects after treatment of patients with thyroid cancer on
the basis of catamless data of paper case reports, formalized and transformed into an electronic form for statistical
analysis using Data Mining.
Materials and Methods. The study was carried out by means of analysis of 315 case reports, where the information
regarding disease course was selected and transformed to the electronic database (100 patients — 86 females
and 14 males). There were 43 patients with long-term oncological effects, including: metastases in 22 (51%);
second cancer in 8 patients (19%); relapses in 13 patients (30%). In addition to oncological effects, 13 patients in
this group also had therapeutic complications, which were also included to the database. Fifty-seven individuals
had only therapeutic effects of treatment. Taking into account the therapeutic effects of the patients mentioned
above, the total number of therapeutic complications was 218 cases. Statistical processing was carried out using
nonparametric statistics using the Statistica Basic Academic 13 for Windows package.
Outcomes. Taking radionuclide treatment (RNT) into consideration, patients without long-term oncological effects
had a longer treatment duration, more courses of the RNT, higher total activity during RNT and a longer duration
before ablation, compared to patients with long-term oncological effects. These conclusions can be considered as a
scientifc basis for the calculation of a single dose of activity during RNT and its duration for patients with a burden
of somato-neurological anamnesis. In addition, patients without long-term oncological effects had twice less cases
of germination of a tumor through a capsule and lower body mass index. In this case, extrathyroidal extension is
a risk factor for long-term metastasis, but it is not a risk factor for local recurrence and the appearance of secondary
cancers. A typical histological form for patients with oncologic effects was papillary adenocarcinoma. As a risk
factor for the occurrence of local relapses, an increased longevity of lactation in the reproductive period and
a lower dose of maintenance therapy has been determined. As a risk factor for the occurrence of secondary cancers,
the low duration of maintenance therapy and premenopausаl status for women has been determined. It was shown
that the use of RNT as a component of special treatment of thyroid cancer increases the incidence of circulatory
system diseases in 2.1 times.
Conclusions. Data Mining statistical analysis made it possible to detect the relationship between long-term
oncological effects of thyroid cancer and the characteristics of RNT, the degree of extrathyroidal extension, the
dose of maintenance therapy, the duration of lactation in the reproductive period, and some other factors, as well
as to note the increase in the incidence diseases of the circulatory system compared with the population data by
2.1 times, in particular the frequency of the most widespread medical entities (CHD and HT) by 2.9 times and
1.85 times respectively.
Keywords: thyroid cancer, treatment long-term effects, statistical analysis, medical informatics.
2018, vol XXVI, # 4, page 252
O. P. LUKASHOVA
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
ULTRASTRUCTURE OF ENDOCRINE ORGAN CELLS IN LONG-TERM PERIOD AFTER TOTAL AND PARTIAL EXPOSURE AT A SMALL DOSE
Purpose. Study of small dose radiation effect on the structural and functional state of endocrine organ cells in the
long term after the total and partial fractional irradiation of rats at a dose of 0.75 Gy.
Methods. The ultrastructure of the thyroid gland, spermatogenic epithelium, adrenal cortex, pineal gland and
adenohypophysis 6 months after fractional total x-irradiation, individual head irradiation, and individual body
irradiation of rats at a total dose of 0.75 Gy were investigated using electron microscopy standard Methods.
Outcomes. It has been found that six months after total exposure, there are noticeable disturbances in the
ultrastructure of the examined endocrine gland cells, which indicate the processes of inhibition of the functional
activity of these organs. The effect of radiation on the head under the same conditions leads to identical changes;
in cases when only the body is irradiated, the structural and functional state of all investigated organs corresponds
to the age control.
Conclusions. Ultrastructural disturbances of endocrine cells in experimental animals indicate a decrease in
their functional activity in the long term after a general dose of radiation and depletion of the function. Parallel
inhibition of the activity of the target organs and regulatory organs of the endocrine system may indicate the
secondary nature of the hypofunction of the target glands by reducing the level of the corresponding tropical
pituitary hormones. The irradiation of only the heads of experimental animals causes changes in the cells of the
endocrine glands, similar to those observed with total irradiation.Ultrastructural disturbances of endocrine cells in
the experimental animals indicate decreased functional activity in the long term after a general dose radiation and
function depletion. Parallel inhibition of the activity of the target organs and endocrine system regulatory organs
may indicate a secondary nature of the hypofunction of the target glands by reducing the level of the corresponding
tropic pituitary hormones. The irradiation of only the heads of experimental animals causes changes in the cells of
the endocrine glands, similar to those observed in total irradiation. The irradiation of only the body of experimental
animals does not lead to radiation changes in the cells of the endocrine organs. The study shows that when exposed
to radiation in small doses, the brain is the critical organ, that is, radiophysical areas that are involved in the higher
regulation of the endocrine system. When being in the zone of ionizing radiation, head shielding may be useful.
Keywords: irradiation, small doses, long terms, endocrine organs, ultrastructure.
LITERATURE REVIEW
2018, vol XXVI, # 4, page 262
H. V. KULINICH, N. S. PIDCHENKO, L. V. ROHACHEVSKA
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
MALIGNANCY AND DIABETES MELLITUS: INTERRELATION, DIAGNOSIS PECULIARITIES, OBSERVATION (LITERATURE REVIEW)
The article deals with the publications of Ukrainian and foreign authors concerning interrelation of oncological
diseases and diabetes mellitus as well as the impact of diabetes mellitus on the risks of neoplasms development,
diagnosis peculiarities, treatment and monitoring of the patients. A retrospective assessment of case reports of 870
patients with a combination of oncological pathology and type 2 diabetes mellitus (type 2 diabetes), who were being
observed at SI Grigoriev Institute for Medical Radiology of NAMS of Ukraine from 2012 to 2018, is provided. The
paper will make it possible to make specialists familiar with multidisciplinary approaches in the treatment of patients
with comorbid pathology, to improve the prognosis of the results of treatment of cancer patients.
Keywords: oncologic diseases, diabetes mellitus, clinical features, metabolic syndrome, metformin, survival.
2018, vol XXVI, # 4, page 271
М. V. KRASNOSELSKYI1, 2, A. N. BELIY1, 2, O. N. ASTAPIEVA2, R. A. PIDLISNIY1
1 SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine», Kharkіv
2 Kharkiv National Medical University
DIAGNOSTIC ERRORS IN COMPUTER TOMOGRAPHY. THE CASE OF DETECTION OF EARLY COLON CANCER AT SYNCHRONOUSE KIDNEY CANCER
The article describes the case of synchronous cancer of the kidney and colon. At the patient at the diagnostic stage
cancer of the right kidney was revealed. A CT-protocol of 3 floors with intavenouse contrasting was performed.
Cancer of the descending colon, which was not visualized on CT was detected only with laparotomy. The patient
undergone right-sided nephrectomy and Mikulich operation.
Keywords: primary multiple malignant process, colon cancer, kidney cancer, computed tomography, surgical treatment.
DISCUSSION
2018, vol XXVI, # 4, page 275
S. A. AMIRAZYAN1, 2, A. A. FATIEIEV 2
1 Karazin Kharkiv National University
2 Kharkiv National Medical University
RADIATION MEDICINE IN HIGH SCHOOL
The second wave of the nuclear arms race that we have witnessed can make a nuclear conflict inevitable. Experience
teaches that the capacity of modern medicine, both in education and ability, to provide highly specialized assistance
to a huge number of victims should not be overestimated.
Until the world recognizes the complete immorality of the arms race and the preparation for a nuclear war, mankind
continues to be in danger of extinction.
Keywords: radiation medicine, radiation protection, nuclear conflict, doctor’s role.
2018, vol XXVI, # 4, page 280
V. P. STARENKIY, I. B. SHUSTOV, L. V. ZABOBONINA, L. L. STADNIK
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
MODERN VIEW ON NON-TUMOR DISEASES RADIOTHERAPY
The paper deals with literature review of non-tumor diseases radiotherapy. The treatment efciency in acute
inflammatory processes, keloid cicatrices, fbromatosis. autoimmune ophthalmopathy and some other diseases has
been proved. However, there is need to provide government-sponsored support scheme and method popularization
for X-ray therapy management.
Keywords: radiotherapy, non-tumor disease, government-sponsored scheme.
2018, vol XXVI, # 4, page 287
O. M.ASTAPIEVA, R. M. SPUZYAK, O. M. PASKEVICH, E. P. STEPANOV, S. A. AMIRAZYAN
Kharkiv National Medical University
QUESTIONS OF ORGANIZATIONAL-PEDAGOGICAL AND METHODOLOGICAL SUPPORT OF TEACHING STUDENTS OF MEDICAL FACULTY OF KNMU
One of the tasks of reforming medical care to the population of Ukraine is the adaptation of work programs in
radiology for students of medical faculties of KNMU. Diagnostic radiology involves the use of visualization
capabilities of pathological changes in the organs and systems of patients using modern radiological techniques.
This is the psychological and pedagogical motivation of medical students. Therapeutic radiology allows to increase
the effectiveness of anticancer treatment in 70–80% of cases of malignant tumors.
Training of students includes traditional methodological approaches (lectures, practical exercises, independent
work of students), as well as the wide use of the Internet. In general, it reflects the development trends of medical
science and provides the necessary level of knowledge of future specialists.
Keywords: radiology, work program, information training technologies.
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We are proud to announce the annual scientific conference of young scientists with the international participation, dedicated to the Day of Science in Ukraine. The conference will be held on 20th of May, 2016 and hosted by L.T. Malaya National Therapy Institute, NAMS of Ukraine together with Grigoriev Institute for medical Radiology, NAMS of Ukraine. The leading topic of conference is prophylaxis of the non-infectious disease in different branched of medicine.
of the scientific conference with the international participation, dedicated to the Science Day, «CONTRIBUTION OF YOUNG PROFESSIONALS TO THE DEVELOPMENT OF MEDICAL SCIENCE AND PRACTICE: NEW PERSPECTIVES»
We are proud to announce the scientific conference of young scientists with the international participation, dedicated to the Science Day in Ukraine that is scheduled to take place May 15, 2014 at the GI “L.T. Malaya National Therapy Institute of the National academy of medical sciences of Ukraine”. The conference program will include the symposium "From nutrition to healthy lifestyle: a view of young scientists" dedicated to the 169th anniversary of the I.I. Mechnikov.
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